A dimer ABC:
نویسندگان
چکیده
منابع مشابه
A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer.
The ATP-binding cassette (ABC)-transporter haemolysin (Hly)B, a central element of a Type I secretion machinery, acts in concert with two additional proteins in Escherichia coli to translocate the toxin HlyA directly from the cytoplasm to the exterior. The basic set of crystal structures necessary to describe the catalytic cycle of the isolated HlyB-NBD (nucleotide-binding domain) has now been ...
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The ABC-ATPase GlcV from Sulfolobus solfataricus energizes an ABC transporter mediating glucose uptake. In ABC transporters, two ABC-ATPases are believed to form a head-to-tail dimer, with both monomers contributing conserved residues to each of the two productive active sites. In contrast, isolated GlcV, although active, behaves apparently as a monomer in the presence of ATP-Mg(2+), AMPPNP-Mg(...
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ABC transporters are a superfamily of enzyme pumps that hydrolyse ATP in exchange for translocation of substrates across cellular membranes. Architecturally, ABC transporters are a dimer of transmembrane domains coupled to a dimer of nucleotide binding domains (NBDs): the NBD dimer contains two ATP-binding sites at the intersubunit interface. A current controversy is whether the protomers of th...
متن کاملThe ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state.
BmrA from Bacillus subtilis is a half-size ABC (ATP-binding cassette) transporter involved in multidrug resistance. Although its supramolecular organization has been investigated after reconstitution in a lipid bilayer environment, and shows a dimeric and possibly a tetrameric form, the precise quaternary structure in a detergent-solubilized state has never been addressed. In the present study,...
متن کاملCongruence ABC implies ABC
The ABC conjecture of Masser and Oesterlé states that if (a, b, c) are coprime integers with a+ b+ c = 0, then sup(|a|, |b|, |c|) < cǫ(rad(abc)) 1+ǫ for any ǫ > 0. In [2], Oesterlé observes that if the ABC conjecture holds for all (a, b, c) with 16|abc, then the full ABC conjecture holds. We extend that result to show that, for every integer N , the “congruence ABC conjecture” that ABC holds fo...
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ژورنال
عنوان ژورنال: Bulletin of the London Mathematical Society
سال: 2016
ISSN: 0024-6093,1469-2120
DOI: 10.1112/blms/bdv101